Plakohipaforina

Las Plakohipaforinas son indolaminas que contienen yodo. Son nombradas por su semejanza química con la hipaforina.^[1]^[2] Fueron reportadas por primera vez por ser aislada de la esponja caribeña Plakortis simplex en 2003, plakohipaforinas A-C Las Plakohipaforinas D-F, también encontradas P. simplex, fueron reportadas en 2004.

Plakohipaforina	Nombre	Fórmula química	SMILES
Plakohipaforina	7-Yodo-N,N,N-trimetiltriptófano	C₁₄H₁₇IN₂O₂	OC(=O)C(N(C)(C)C)Cc2cnc1c2cccc1I
Plakohipaforina B	6,7-Diyodo-N,N,N-trimetiltriptófano	C₁₄H₁₆I₂N₂O₂	OC(=O)C(N(C)(C)C)Cc2cnc1c2ccc(I)c1I
Plakohipaforina C	5,7-Diyodo-N,N,N-trimetiltriptófano	C₁₄H₁₆I₂N₂O₂	CN(C)(C)C(C(=O)O)Cc2cnc1c2cc(I)cc1I
Plakohipaforina D	5,6-Diyodo-N,N,N-trimetiltriptófano	C₁₄H₁₆I₂N₂O₂	Ic2cc1c(cc2I)ncc1CC(C(O)=O)N(C)(C)C
Plakohipaforina E	5,6,7-Triyodo-N,N,N-trimetiltriptófano	C₁₄H₁₅I₃N₂O₂	CN(C)(C)C(C(=O)O)Cc1cnc(c(I)c2I)c1cc2I
Plakohipaforina F	6-Cloro-5-yodo-N,N,N-trimetiltriptófano	C₁₄H₁₆ClIN₂O₂	Clc2c1ncc(CC(C(O)=O)N(C)(C)C)c1cc(I)c2

Referencias[editar]

↑ Borrelli, Francesca, et al., 2003. Plakohypaphorines A-C, Iodine-Containing Alkaloids from the Caribbean Sponge Plakortis simplex. European Journal of Organic Chemistry. 2003(2), pp. 284-287.
↑ Borrelli, Francesca, et al., 2004. Iodinated Indole Alkaloids From Plakortis simplex, New Plakohypaphorines and an Evaluation of Their Antihistamine Activity. European Journal of Organic Chemistry. 2004(15), pp. 3227-3232.

Datos: Q9060376

[1] Borrelli, Francesca, et al., 2003. Plakohypaphorines A-C, Iodine-Containing Alkaloids from the Caribbean Sponge Plakortis simplex. European Journal of Organic Chemistry. 2003(2), pp. 284-287.

[2] Borrelli, Francesca, et al., 2004. Iodinated Indole Alkaloids From Plakortis simplex, New Plakohypaphorines and an Evaluation of Their Antihistamine Activity. European Journal of Organic Chemistry. 2004(15), pp. 3227-3232.

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